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KMID : 1039920190260010048
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Neonatal Medicine
2019 Volume.26 No. 1 p.48 ~ p.54
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Comparison of Clinical Factors and Neurodevelopmental Outcomes between Early- and Late-Onset Periventricular Leukomalacia in Very Low Birth Weight Infants
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Bae Mi-Hye
Lee Na-Rae
Han Young-Mi
Park Kyung-Hee
Byun Shin-Yun
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Abstract
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Purpose: To analyze and compare the clinical factors and neurodevelopmental outcomes compare early- and late-onset periventricular leukomalacia (PVL) in very low birth weight infants (VLBWI).
Methods: We performed a retrospective study involving 199 newborn infants weighing <1,500 g admitted to the neonatal intensive care unit between March 2009 and December 2015. VLBWI with PVL were categorized into early- and late-onset PVL groups based on the time of diagnosis based on 28 days of age. We analyzed the clinical factors and neurodevelopmental outcomes between the groups.
Results: The incidence rate of PVL was 10.1% (16/158). The Apgar score at 1 minute and the mean duration of tocolytic therapy were associated with the development of PVL. The incidence rate of premature rupture of membranes (PROM) was significantly higher in the early-onset PVL group (P=0.041). No significant differences were observed in neurodevelopmental outcomes between the early- and late-onset PVL groups.
Conclusion: Results suggest that a higher incidence of PROM was associated with clinical characteristics in the early-onset PVL group. No significant intergroup differences were observed in neurodevelopmental outcomes; however, the Bayley Scales of Infant Development-III scores were lower in the early-onset PVL group.
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KEYWORD
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Leukomalacia, periventricular, Fetal membranes, premature rupture, Infant, very low birth weight
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